Development And Application Of Biomimetic Electrospun Nanofibers In Total Joint Replacement
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چکیده
DEVELOPMENT AND APPLICATION OF BIOMIMETIC ELECTROSPUN NANOFIBERS INTOTAL JOINT REPLACEMENTbyWEI SONGMay 2014Advisor: Dr. Weiping RenMajor: Biomedical EngineeringDegree: Doctor of Philosophy Failure of osseointegration (direct anchorage of an implant by bone formation at the bone‐implant surface) and implant infection (such as that caused by Staphylococcus aureus, S. aureus) are the two main causes of implant failure and loosening. There is a critical need for orthopedic implants that promote rapid osseointegration and prevent bacterial colonization, particularly when placed in bone compromised by disease or physiology of the patients. A better understanding of the key factors that influence cell fate decisions at the bone‐implant interface is required. Our study is to develop a class of “bone‐like” nanofibers (NFs) that promote osseointegration while preventing bacterial colonization and subsequent infections. This research goal is supported by our preliminary data on the preparation of coaxial electrospun NFs composed of polycaprolactone (PCL) and polyvinyl alcohol (PVA) polymers arranged in a core‐sheath shape. The PCL/PVA NFs are biocompatible and biodegradable with appropriate fiber diameter, pore size and mechanical strength, leading to enhanced cell adhesion, proliferation and differentiation of osteoblast precursor cells. The objective is to
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